Analisis Pengaruh Metode Penggerusan Kaplet Paracetamol terhadap Kadar Bahan Aktif Obat

Amanda Aulia, Yuyun Febriani, Tri Puspita Yuliana

Abstract


One of the drugs commonly used by the general public is paracetamol. This drug has relatively mild side effects compared to other drugs, so it is common to be prescribed for compounding pulmonary drugs for patients with certain doses There are two grinding methods used, namely a mortir and a blender. The purpose of this study was determined the variation effects in the dissolution speed and particle size on decreasing levels of paracetamol potency in each grinding methods. UV-Vis Spectrofotometer was used as quantitative methode.  Based on the results, the percentage level of solubility velocity were in mortar: 70.54% aquadest, 115.49% ethanol, 96.10% acetone, 113.20% NaOH. In the blender: 65.44% aquadest, 88.14% ethanol, 48.31% acetone, 98.20% NaOH. Meanwhile, for variations in particle size, the mortar obtained: mesh20 101.82%, mesh40 117.73%, mesh80 80.91%, mesh100 113.20%. In the blender obtained: mesh20 96.98%, mesh40 88.40%, mesh80 69.06%, mesh100 99.11%. Furthermore, the statistical analysis by two-way anova obtained a significance value of 0.059 for variations in dissolution speed and 0.659 in particle size. In conclusion, there was an effect of variations in solvents but did not show an effect of variations in particle size on decreasing levels of active drug ingredients.


Keywords


Active ingredient levels paracetamol, grinding method, solubility rate, particle size, UV- Visible Spectrophotometer

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References


Aprilia, H., & Arumsari, A. (2019). Pengembangan Alat Uji Carik Berbasis Polistiren Divinilbenzen (PSDVB) Dengan Metode Reagent Blending Untuk Identifikasi Bahan Kimia Obat Paracetamol Dalam Jamu. Prosiding Farmasi, 208–212.

Bestari, A. N., Sulaiman, T. S., & Purnamasari, D. A. (2017). Pengaruh pengecilan ukuran partikel pada kasus pembuatan pulveres dari tablet ibuprofen terhadap kecepatan dan profil disolusi serta stabilitasnya. Majalah Farmaseutik, 13(1), 45–55.

Depkes, R. I. (1995). Farmakope indonesia edisi IV. Jakarta: Departemen Kesehatan Republik Indonesia, 45.

Dipahayu, D., & Permatasari, S. N. (2019). Pengaruh Metode Penggerusan Tablet Vitamin C Terhadap Kadar Bahan Aktif. Jurnal Kimia Riset, 4(2), 94–99.

Farmakope, I. (2009). farmakope indonesia (Edisi Empa). depkes RI.

Fathul, A. (2020). Studi Literatur: Gambaran Pengetahuan Masyarakat Tentang Swamedikasi Demam. Universitas_Muhammadiyah_Mataram.

Fauzi, L. C. (2016). Analisis Kualitatif Bahan Baku Paracetamol Metode Konvensional. Annals of Clinical Biochemistry.

Gandjar, I. G., & Rohman, A. (2012). Analisis obat secara spektrofotometri dan kromatografi. Yogyakarta: Pustaka Pelajar, 316, 368–381.

Liviandari, R., & Husni, P. (2023). Strategi Pencegahan dan Peningkatan Pengawasan BPOM Terkait Kasus Cemaran EG/DEG dalam Sirup Obat. Journal of Pharmaceutical and Sciences, 1906–1911.

MUFTI, R. H. (2018). UJI DISOLUSI TERBANDING TABLET PARASETAMOL PRODUK GENERIKDAN MERK. UNIVERSITAS MUHAMMADIYAH PURWOKERTO.

Novitri, S. A., Betha, O. S., Maryam, S., Saibi, Y., & Siregar, B. J. (2021). Gambaran Mutu Racikan Puyer Di Apotek Kecamatan Jagakarsa Dan Pasar Minggu. Jurnal Endurance, 6(3), 650–658.

Nugroho, D., Kabir, L., Joo, Y. J., Cho, K. Y., Nanan, S., Chanthai, S., Benchawattananon, R., & Oh, W.-C. (2024). Photocatalytic performance with electrochemical effects for ZnO/Graphene Quantum Dots/CdSe nanocomposite toward ciprofloxacin antibiotics and paracetamol degradation under visible light. Materials Today Chemistry, 42, 102393.

Pratama, B. A., & Hastuti, S. (2024). Pengaruh Pengetahuan dan Sikap Ibu Tentang Gagal Ginjal Akut Progresif Atipikal (GGAPA) terhadap Swamedikasi Penggunaan Obat Sirup di Kabupaten Sukoharjo. CERATA Jurnal Ilmu Farmasi, 15(1), 29–42.

Rahman, H., & Patmasari, D. A. M. (2019). Kajian Penggunaan Obat Dan Evaluasi Sediaan Kapsul Racikan Paracetamol–Diazepam. Jurnal Politeknik Tegal, 8(2), 11.

Sari, A. I. N., & Kuntari, K. (2019). Penentuan Kafein dan Parasetamol dalam Sediaan Obat secara Simultan Menggunakan Spektrofotometer UV-Vis. Indonesian Journal of Chemical Analysis (IJCA), 2(01), 20–27.

Tulandi, G. P. (2015). Validasi Metode Analisis untuk Penetapan Kadar Parasetamol dalam Sediaan Tablet Secara Spektrofotometri Ultraviolet. Pharmacon, 4(4).

Utomo, N. P. (2016). Efek Analgesik Kombinasi Kurkumin Dan Parasetamol Pada Mencit Yang Diinduksi Asam Asetat Menggunakan Analisis Isobologram.

Widhiarso, W. (2020). Pengkategoriam data menggunakan statistik hipotetik dan statistik empirik. Diunduh Dari Http://Widhiarso. Staff. Ugm. Ac. Id/Wp/Pengategorian-Data-Denganmenggunakan-Statistik-Hipotetik-Dan-Statistik-Empirik/, Tanggal, 1.

Widiasmini, N. P. E., Jaya, M. K. A., & Santika, I. W. M. (n.d.). Perbandingan Stabilitas Obat Racikan yang Dipreparasi Menggunakan Mortir dan Tablet Crusher di Apotek Sarana Pelayanan Kesehatan Primer.

Yuliani, S. H. (2023). Praktik Peracikan Obat Berorientasi Pasien. Sanata Dharma University Press.




DOI: https://doi.org/10.31764/lf.v6i1.29049

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