Aktivitas Antioksidan Formula Nano Gel Kombinasi Daun Sonneratia caseolaris dan Trigona sp. Propolis

Sabina Guseynova, Paula Mariana Kustiawan

Abstract


Sonneratia caseolaris and Kelulut propolis (Trigona sp.) are used by people to protect the face from sun exposure. Both have antioxidant potential, but until now no one has used the combination of these two natural ingredients as an antioxidant. The aims of this research were to obtain antioxidant activity from nano gel formula combination of Sonneratia caseolaris and Trigona sp Propolis extracts. The nano gel formulation was made into 3 formulations with concentrations of F1 (1:1), F2 (1:2) and F3 (2:1) by evaluating the preparation and antioxidant activity by using DPPH method. The evaluation results showed that all of the nano gel formulas were in accordance with the standard characteristics of the preparation and strong antioxidant activities with IC50 (µg/mL) result : F1 (17.568), F2 (35.112) and F3 (14.503). Based on the IC50 results, the greatest antioxidant activity was obtained in Formula 1.


Keywords


Antioxidant; Extracts; Nano Gel; Sonneratia caseolaris; propolis

Full Text:

PDF

References


Ali, S. M., & Yosipovitch, G. (2013). Skin pH: from basic science to basic skin care. Acta Dermato-Venereologica, 93(3).

Anastasya, Rahmat, D., & Budiati, A. (2020). Formulation and activity of gel containing nanoparticles of javanese turmeric extract as antiacne. Jurnal Ilmu Kefarmasian Indonesia, 18(1), 118–122.

Badan Standarisasi Nasional. (1996). SNI 16-4399-1996: Sediaan Tabir Surya. Badan Standardisasi Nasional 16-4399-1996, 16(4399), 1–3.

Batistuta, M. A., Zulfa, A. F., & Kustiawan, P. M. (2022). Aktivitas Antioksidan Fraksi N-Heksan Propolis Lebah Kelulut (Geniotrigona thoracica). Medical Sains : Jurnal Ilmiah Kefarmasian, 7(2), 63–70. https://doi.org/10.37874/ms.v7i2.340

Binuni, R., Maarisit, W., Hariyadi, H., & Saroinsong, Y. (2020). Uji Aktivitas Antioksidan Ekstrak Daun Mangrove Sonneratia alba Dari Kecamatan Tagulandang, Sulawesi Utara Menggunakan Metode DPPH. Biofarmasetikal Tropis, 3(1), 79–85. https://doi.org/10.55724/j.biofar.trop.v3i1.260

Bioorganik, M. K., Pengampu, D., Antonius, I., Cahyana, H., & Dpph, P. (2020). Peredaman Radikal Bebas 2 , 2-Diphenyl-1-. January.

Husni, P., Ruspriyani, Y., & Hasanah, U. (2023). FORMULASI DAN UJI STABILITAS FISIK SEDIAAN LOTION EKSTRAK KERING KULIT KAYU MANIS (Cinnamomum burmannii). Jurnal Sabdariffarma, 10(1), 1–7. https://doi.org/10.53675/jsfar.v10i1.396

Iskandar, B., Sidabutar, S. E. B., & Leny, L. (2021). Formulasi dan Evaluasi Lotion Ekstrak Alpukat (Persea Americana) sebagai Pelembab Kulit. Journal of Islamic Pharmacy, 6(1), 14–21. https://doi.org/10.18860/jip.v6i1.11822

Jusnita, N., & Nasution, K. (2019). Formulasi Nanoemulsi Ekstrak Daun Kelor (Moringa oleifera Lamk). Industria: Jurnal Teknologi Dan Manajemen Agroindustri, 8(3), 165–170. https://doi.org/10.21776/ub.industria.2019.008.03.1

Khairunnisa, K., Mardawati, E., & Putri, S. H. (2020). Karakteristik Fitokimia dan Aktivitas Antioksidan Ekstrak Propolis Lebah Trigona Sp. Jurnal Industri Pertanian, 2(1), 124–129.

Kharisma, D. N. I., & Safitri, C. I. N. H. (2020). Formulasi dan Uji Mutu Fisik Sediaan Gel Ekstrak Bekatul ( Oryza sativa L .). Artikel Pemakalah Paralel, 228–235.

Kustiawan, P. M., Aziz, A., & Yuliawan, V. N. (2022). Antioxidant and Antibacterial Activity of Various Fractions of Heterotrigona itama Propolis Found in Kutai Kartanegara. Open Access Macedonian Journal of Medical Sciences, 10(A), 531–534.

Kustiawan, P. M., Yanti, E. N., Nisa, K., Zulfa, A. F., & Batistuta, M. A. (2023). Bioactivity of Heterotrigona itama propolis as anti-inflammatory: A review. Biointerface Research in Applied Chemistry, 13(4), 326.

Kustiawan, P. M., Zulfa, A. F., Batistuta, M. A., Hanifa, D. N. C., & Setiawan, I. M. (2022). Comparative Analysis of Phytochemical, Total Phenolic Content, Antioxidant and Antibacterial Activity of Two Species Stingless Bee Propolis from East Kalimantan. Malaysian Journal of Medicine and Health Sciences, 18(7), 50–55. https://doi.org/10.47836//mjmhs18.4.8

Mardhiyyah, K., Yunita Intan Ryandini, & Yopi Hermawan. (2021). Red and White Galangal Puree Antioxidant Activity and Phytochemistry Screening. Jurnal Jamu Indonesia, 6(1), 23–31. https://doi.org/10.29244/jji.v6i1.174

Mohiudin, A. K. (2019). Skin Care: Formulation and Use. American Journal of Dermatological Research and Reviews, 2(8), 238–27.

Prasetyo, E., Kiromah, N. Z. W., & Rahayu, T. P. (2021). Uji Aktivitas

Antioksidan Menggunakan Metode DPPH (2,2-difenil-1-pikrilhidrazil) Terhadap Ekstrak Etanol Kulit Buah Durian (Durio zibethinnus L.) dari Desa Alasmalang Kabupaten Banyumas. Jurnal Pharmascience, 8(1), 75. https://doi.org/10.20527/jps.v8i1.9200

Sari, B. P., & Kustiawan, P. M. (2023). Antioxidant Activity of Extract Combination from Averrhoa bilimbi L. Leaves and Stingless Bee Honey. Indonesian Journal of Pharmaceutical Science and Technology, 1(1), 28–34. https://doi.org/10.24198/ijpst.v0i0.45987

Sayuti, N. A. (2015). Formulasi dan Uji Stabilitas Fisik Sediaan Gel Ekstrak Daun Ketepeng Cina (Cassia alata L.). Jurnal Kefarmasian Indonesia, 5(2), 74–82. https://doi.org/10.22435/jki.v5i2.4401.74-82

Sethi, M., Rana, R., Sambhakar, S., & Chourasia, M. K. (2024). Nanocosmeceuticals: Trends and Recent Advancements in Self Care. AAPS PharmSciTech, 25(3), 51.

Setyawan, R., Dwi, C., Masrijal, P., Hermansyah, O., Rahmawati, S., Intan, R., Sari, P., & Cahyani, A. N. (2023). Formulasi, Evaluasi dan Uji Stabilitas Fisik Sediaan Gel Antioksidan Ekstrak Tali Putri (Cassytha filiformis L). Bencoolen Journal of Pharmacy 2023, 3(1), 27–33.

Syamsul, E. S., Supomo, & Jubaidah, S. (2020). Karakterisasi Simplisia dan Uji Aktivitas Antioksidan Ekstrak dan Fraksi Daun Pidada Merah (Sonneratia caseolaris L). KOVALEN: Jurnal Riset Kimia, 6(3), 184–190. https://doi.org/10.22487/kovalen.2020.v6.i3.15319

Wijaya, H., Novitasari, & Jubaidah, S. (2018). Perbandingan Metode Ekstraksi Terhadap Rendemen Ekstrak Daun Rambui Laut (Sonneratia caseolaris L. Engl). Jurnal Ilmiah Manuntung, 4(1), 79–83.

Yuliawan, V. N., Aziz, A., & Kustiawan, P. M. (2021). Uji Fitokimia Fraksi Etil Asetat Dari Propolis Lebah Kelulut Heterotrigona Itama Asal Kutai Kartanegara Pengumpulan sampel. 2(2), 131–137.

Zaky, M., Rusdiana, N., & Darmawati, A. (2021). Formulasi dan Evaluasi Fisik Sediaan Gel Antioksidan Ekstrak Etanol 70% Daun Belimbing Wuluh (Averrhoa bilimbi L.) Menggunakan Metode DPPH. Jurnal Farmagazine, 8(2), 26. https://doi.org/10.47653/farm.v8i2.556

Zamzam, M. Y., & Indawati, I. (2018). Formulasi Dan Uji Stabilitas Lotion Ekstrak Formulation and Stability Test Lotion of. Medimuh …, 1(1), 95–108.




DOI: https://doi.org/10.31764/lf.v5i2.23417

Refbacks

  • There are currently no refbacks.


EDITORIAL OFFICE: