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Efektivitas Ekstrak Etanol Daun Namnam (Cynometra cauliflora L) Sebagai Antibakteri Pada Formulasi Sediaan Gel Hand Sanitizer | Anliza | Lumbung Farmasi: Jurnal Ilmu Kefarmasian

Efektivitas Ekstrak Etanol Daun Namnam (Cynometra cauliflora L) Sebagai Antibakteri Pada Formulasi Sediaan Gel Hand Sanitizer

Syarah Anliza, Hamtini Hamtini, Nurmeily Rachmawati

Abstract


ABSTRAK

Pandemi Covid 19 yang menimpa dunia saat ini menjadikan peningkatan kebutuhan akan perilaku hidup bersih dan sehat. Salah satu dalam peningkatannya yaitu kesadaran akan mencuci tangan dan mulai terlihat semenjak covid-19 masuk ke Indonesia. Penggunaan gel antiseptik yang dinilai lebih praktis bisa menjadi pilihan. Bahan dasar yang biasa digunakan adalah alkohol, namun dengan bahan tersebut dapat menyebabkan dehidrasi pada kulit. Oleh karena itu maka diperlukan alternatif bahan aktif yaitu bahan alam. Salah satu bahan alam yang digunakan daun namnam. Ekstrak daun namnam yang memiliki kandungan tanin dan flavonoid dapat sebagai antibakteri. Beberapa penelitian menyatakan bahwa tanaman yang mengandung tannin dan flavonoid dapat sebagai sediaan gel hand sanitizer. Tujuan dari penelitian ini yaitu untuk mengetahui potensi ekstrak etanol daun namnam pada formulasi sediaan gel hand sanitizer terhadap bakteri Staphylococcus aureus ATCC 25923. Metode yang digunakan maserasi untuk ekstrak dan difusi agar untuk aktivitas bakteri. Formulasi sediaan gel yang digunakan pada penelitian ini menggunakan gelling agent CMC Na dengan 5 formulasi. Hasil menunjukkan bahwa sampel F1, F2, F3, dan F4 dapat menghambat bakteri dengan kategori kuat, sedangkan sampel F5 termasuk kategori medium atau cukup kuat. Kesimpulan dari penelitian ini adalah sampel F1 dengan konsentrasi ekstrak etanol daun namnam sebesar 20% dan memiliki evaluasi sediaan gel yang baik dan memenuhi syarat.    


Kata kunci : Ekstrak etanol; Daun namnam; Gel hand sanitizer; Staphylococcus aureus.


ABSTRACT

The COVID-19 pandemic that has hit the world today has increased the need for clean and healthy living behaviors. One of the improvements that have been seen since Covid-19 occurred in Indonesia is awareness of hand washing. The use of an antiseptic gel is considered a more practical option. The basic ingredient commonly used is alcohol, but these ingredients can cause dehydration of the skin. Therefore, alternative active ingredients are needed, namely natural ingredients. One of the natural ingredients used by namnam leaves. Namnam leaf extract which contains tannins and flavonoids can act as an antibacterial. Several studies have shown that plants containing tannins and flavonoids can be used as a hand sanitizer gel preparation. The purpose of this study was to determine the potential of ethanol extract of Namnam leaves in the formulation of hand sanitizer gel preparations against Staphylococcus aureus ATCC 25923 bacteria. The methods used were maceration for extracts and agar diffusion for bacterial activity. The gel formulation used in this study was the gelling agent CMC Na with 5 formulations. The results showed that  samples F1, F2, F3, and F4 could inhibit bacteria in the strong category, while sample F5 was in the medium category or quite strong. The conclusion of this study is that sample F1 with extract ethanol of nam-nam leaves in 20% has a good evaluation of gel preparations and met the requirements.


Keywords : Ethanol extract; Namnam lef; Hand sanitizer gel; Staphylococcus aureus.



Keywords


Ethanol extract; Namnam lef; Hand sanitizer gel; Staphylococcus aureus.

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References


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DOI: https://doi.org/10.31764/lf.v3i2.9157

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