Efektivitas Antihipertensi Jamu Hitenfit pada Tikus Putih Jantan (Rattus norvegicus) Galur Wistar yang Diinduksi Prednison dan NaCl 2,5%

Muhammad Nurul Hasanudin, Huda Nur Arifin, Meki Pranata, Muhammad Alfian, Mochamad Luqni Maulana

Abstract


Hipertensi merupakan faktor risiko penyakit kardiovaskular. Jamu Hitenfit yang mengandung ekstrak daun salam, seledri, tempuyung, meniran, dan pegagan secara empiris digunakan sebagai antihipertensi, namun belum dievaluasi secara pra-klinis. Penelitian ini bertujuan mengevaluasi efektivitas antihipertensi Jamu Hitenfit pada tikus putih jantan galur Wistar yang diinduksi hipertensi. Penelitian menggunakan rancangan pre-post test control design dengan enam kelompok. Hipertensi diinduksi menggunakan kombinasi prednison (18 mg/100 mL) dan NaCl 2,5% selama 7 hari. Kelompok perlakuan menerima Jamu Hitenfit dosis 400, 800, dan 1200 mg/70 kgBB dua kali sehari selama 7 hari, sedangkan captopril digunakan sebagai kontrol positif. Tekanan darah diukur menggunakan Non-Invasive Blood Pressure CODA sebelum induksi, setelah induksi, dan setelah terapi. Data dianalisis menggunakan One-Way ANOVA dilanjutkan uji post-hoc LSD. Hasil menunjukkan bahwa induksi meningkatkan tekanan darah sistolik hingga 141–147 mmHg. Jamu Hitenfit secara signifikan menurunkan tekanan darah dibandingkan kontrol negatif (p<0,05), dengan penurunan sistolik sebesar 27,4%, 26,1%, dan 23,7% pada dosis 400, 800, dan 1200 mg/70 kgBB. Efektivitas ketiga dosis tidak berbeda bermakna dibandingkan captopril (p>0,05). Jamu Hitenfit pada dosis 400, 800, dan 1200 mg/70 kgBB efektif menurunkan tekanan darah pada tikus hipertensi serta dosis 400 mg/70 kgBB sebagai dosis optimal.

Keywords


Hipertensi; Jamu Hitenfit; Rattus norvegicus; Sistolik; Diastolik

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References


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DOI: https://doi.org/10.31764/lf.v7i2.40283

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