Eksplorasi Potensi Antibakteri Senyawa Xanton Dalam Garcinia mangostana L. : Review

Intan Khoirunnisa, Winasih Rachmawati, Elis Susilawati

Abstract


Xanthone compounds are a group of secondary metabolites commonly found in Garcinia mangostana plants. Several studies have shown that the content of these compounds in mangosteen plants exhibits antibacterial activity against both Gram-positive and Gram-negative bacteria. This review aims to summarize various findings related to the antibacterial activity of mangosteen, both in extract form and pure xanthone compounds, as well as their mechanisms. A comprehensive literature search was conducted through PubMed, Mendeley, and Google Scholar databases using relevant keywords. Articles that met the inclusion criteria were reviewed to identify findings related to mangosteen's antibacterial activity. The results showed that several mangosteen extracts with different solvents, such as ethanol, methanol, and n-hexane, exhibited different metabolite profiles and activities against Gram-positive and Gram-negative bacteria, including Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Among the various xanthone compounds, α-mangostin is the most extensively studied and has shown potential antibacterial activity, although other xanthone metabolites may exhibit similar activity. The antibacterial mechanisms of this compound include membrane damage, increased permeability, and inhibition of biochemical pathways for growth. In conclusion, xanthone compounds have great potential as natural antibacterial candidates, but the exploration of specific metabolites is still limited to α-mangostin, highlighting the need for further exploration of xanthone metabolites and their relationship with antibacterial activity.


Keywords


antibakteri; α-mangostin; Garcinia mangostana; xanton

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References


Abdallah, H. M., El-Bassossy, H. M., Mohamed, G. A., El-Halawany, A. M., Alshali, K. Z., & Banjar, Z. M. (2017). Mangostanaxanthones III and IV: advanced glycation end-product inhibitors from the pericarp of Garcinia mangostana. Journal of Natural Medicines, 71(1), 216–226. https://doi.org/10.1007/s11418-016-1051-8

Ahmad, M. I., Keach, J. E., Behl, T., & Panichayupakaranant, P. (2019). Synergistic effect of α-mangostin on antibacterial activity of tetracycline, erythromycin, and clindamycin against acne involved bacteria. Chinese Herbal Medicines, 11(4), 412–416. https://doi.org/10.1016/j.chmed.2019.03.013

Albuquerque, B. R., Dias, M. I., Pinela, J., Calhelha, R. C., Pires, T. C. S. P., Alves, M. J., Corrêa, R. C. G., Ferreira, I. C. F. R., Oliveira, M. B. P. P., & Barros, L. (2023). Insights into the Chemical Composition and In Vitro Bioactive Properties of Mangosteen (Garcinia mangostana L.) Pericarp. Foods, 12(5), 994. https://doi.org/10.3390/foods12050994

Al-Massarani, S., El Gamal, A., Al-Musayeib, N., Mothana, R., Basudan, O., Al-Rehaily, A., Farag, M., Assaf, M., El Tahir, K., & Maes, L. (2013). Phytochemical, Antimicrobial and Antiprotozoal Evaluation of Garcinia Mangostana Pericarp and α-Mangostin, Its Major Xanthone Derivative. Molecules, 18(9), 10599–10608. https://doi.org/10.3390/molecules180910599

Anam, K., Munandar, R., Wulandari, O. N., Lestari, A., Farada, R. E., Hudiyanti, D., & Aminin, A. L. N. (2023). Chemical Composition, Antioxidant Activities, and Total Phenolic Content of Combination of Mangosteen (Garcinia mangostana L.) Peel-Kodavan (Centella asiatica L. Urban) Fractions. Tropical Journal of Natural Product Research, 7(1). https://doi.org/10.26538/tjnpr/v7i1.20

Anggraini, S. W., Erikania, S., & Maritha, V. (2022). Antibacterial Activity of Mangosteen Bark Fraction (Garcinia Mangostana L.) Salmonella Typhi ATCC 13311. Journal of Vocational Health Studies, 5(3), 139. https://doi.org/10.20473/jvhs.V5.I3.2022.139-145

Chaiwarit, T., Kantrong, N., Sommano, S. R., Rachtanapun, P., Junmahasathien, T., Kumpugdee-Vollrath, M., & Jantrawut, P. (2021). Extraction of Tropical Fruit Peels and Development of HPMC Film Containing the Extracts as an Active Antibacterial Packaging Material. Molecules, 26(8), 2265. https://doi.org/10.3390/molecules26082265

Diop, M., Guitoula, C., Tamouh, A. G., Youbong, T., Daffé, S. M. M., Ndoye, M., Gueye, M. W., Wone, F., Ngom, M., Seck, M., Youm, N., Bassoum, O., Lakhe, N. A., Ba, P. S., Faye, A., & Gning, S. B. (2025). Prevalence of bacterial infections and factors associated with death related to these infections in two medical departments of a tertiary hospital in Dakar, Senegal. IJID Regions, 15, 100623. https://doi.org/10.1016/j.ijregi.2025.100623

Ge, R., Zhao, H., Tang, Q., Chandarajoti, K., Bai, H., Wang, X., Zhang, K., Ye, W., Han, X., Wang, C., & Zhou, W. (2024). A novel α-mangostin derivative synergistic to antibiotics against MRSA with unique mechanisms. Microbiology Spectrum, 12(12). https://doi.org/10.1128/spectrum.01631-24

Ginting, J. G., Br. Singarimbun, N., Daeli, M. C. Y., Simanjuntak, H. A., Purba, H., Br. Barus, L., & Zega, D. F. (2023). Inhibition Test of Ethanol from Extract Mangosteen Leaves (Garcinia mangostana L.) as an Acne Antibacterial. Jurnal Pembelajaran Dan Biologi Nukleus, 9(3), 659–667. https://doi.org/10.36987/jpbn.v9i3.5066

Gondokesumo, M. E., Pardjianto, B., Sumitro, S. B., Widowati, W., & Handono, K. (2019). Xanthones Analysis and Antioxidant Activity Analysis (Applying ESR) of Six Different Maturity Levels of Mangosteen Rind Extract (Garcinia mangostana Linn.). Pharmacognosy Journal, 11(2), 369–373. https://doi.org/10.5530/pj.2019.11.56

Górecka, H., Guźniczak, M., Buzalewicz, I., Ulatowska-Jarża, A., Korzekwa, K., & Kaczorowska, A. (2025). Alpha-Mangostin: A Review of Current Research on Its Potential as a Novel Antimicrobial and Anti-Biofilm Agent. International Journal of Molecular Sciences, 26(11), 5281. https://doi.org/10.3390/ijms26115281

Hendiani, I., Susanto, A., Carolina, D. N., Ibrahim, R., & Balatif, F. F. (2020). Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of mangosteen (Garcinia mangostana Linn.) rind extract against Aggregatibacter actinomycetemcomitans. Padjadjaran Journal of Dentistry, 32(2). https://doi.org/10.24198/pjd.vol32no2.27366

Ho, L. Y., Lim, Y. Y., Tan, C. P., & Siow, L. F. (2018). Comparison of physicochemical properties and aqueous solubility of xanthone prepared via oil-in-water emulsion and complex coacervation techniques. International Journal of Food Properties, 21(1), 784–798. https://doi.org/10.1080/10942912.2018.1446022

Ibrahim, S. R. M., Mohamed, G. A., Khayat, M. T. A., Ahmed, S., & Abo‐Haded, H. (2019). Garcixanthone D, a New Xanthone, and Other Xanthone Derivatives From Garcinia mangostana Pericarps: Their α‐Amylase Inhibitory Potential and Molecular Docking Studies. Starch - Stärke, 71(7–8). https://doi.org/10.1002/star.201800354

Indratmoko, S., Issusilaningsih, E., & Pangesti, H. M. (2022). Pengembangan SNEDDS Ekstrak Kulit Buah Manggis (Garcinia mangostana L.) Sebagai Antibakteri Staphylococcus aureus. Jurnal Ilmiah Farmasi, 11(3), 269–175.

Janardhanan, S. (2017). Antimicrobial Effects of Garcinia Mangostana on Cariogenic Microorganisms. Journal Of Clinical And Diagnostic Research. https://doi.org/10.7860/JCDR/2017/22143.9160

Khaw, K. Y., Chong, C. W., & Murugaiyah, V. (2020). LC-QTOF-MS analysis of xanthone content in different parts of Garcinia mangostana and its influence on cholinesterase inhibition. Journal of Enzyme Inhibition and Medicinal Chemistry, 35(1), 1433–1441. https://doi.org/10.1080/14756366.2020.1786819

Kumar, M. D., & Kirthana, K. (2019). Screening of Antioxidant Capacity, Anti-Inflammatory Activity, Anti-Bacterial Activity, And Phytochemical Constituents of Mangosteen Extract (Garcinia Mangostana). International Journal for Research in Applied Science and Engineering Technology, 7(6), 1096–1102. https://doi.org/10.22214/ijraset.2019.6190

Li, P., Yang, Z., Tang, B., Zhang, Q., Chen, Z., Zhang, J., Wei, J., Sun, L., & Yan, J. (2020). Identification of Xanthones from the Mangosteen Pericarp that Inhibit the Growth of Ralstonia solanacearum. ACS Omega, 5(1), 334–343. https://doi.org/10.1021/acsomega.9b02746

Liang, X., Hu, Y., Li, J., Chang, A. K., Tao, X., Li, Y., Liu, W., Pi, K., Yuan, J., & Jiang, Z. (2020). Identification and Pharmacokinetics of Quinone Reductase 2 Inhibitors after Oral Administration of Garcinia mangostana L. Extract in Rat by LC–MS/MS. Journal of Agricultural and Food Chemistry, 68(43), 11975–11986. https://doi.org/10.1021/acs.jafc.0c04439

Liza, P. (2021). Novel antimicrobial activities of self-nanoemulsifying drug delivery system (SNEDDS) ethyl acetate fraction from Garcinia mangostana L. peels against Staphylococcus epidermidis: Design, optimization, and in vitro studies. Journal of Applied Pharmaceutical Science. https://doi.org/10.7324/JAPS.2021.110313

Majid, S. F., Wilapngga, A., & Royani, S. (2024). Skrining Fitokimia Ekstrak etanol Daun Manggis (Garcinia mangostana L.) dan Uji Kemampuan Sebagai Antibakteri. Jurnal Ilmiah Farmasi Akademi Farmasi, 7(1), 93–99.

Mamat, S. F., Azizan, K. A., Baharum, S. N., Noor, N. M., & Aizat, W. M. (2020). GC-MS and LC-MS analyses reveal the distribution of primary and secondary metabolites in mangosteen (Garcinia mangostana Linn.) fruit during ripening. Scientia Horticulturae, 262, 109004. https://doi.org/10.1016/j.scienta.2019.109004

Muchtaridi, M., Prasetio, M., Mekar Saptarini, N., & Amelia Saputri, F. (2018). High Performance Liquid Chromatography For Α-Mangostin Analysis In Mangosteen Pericarp Extract For Routine Analysis With Photodiode Array Detector. Rasayan Journal of Chemistry, 11(3), 973–978. https://doi.org/10.31788/RJC.2018.1132098

Naghavi, M., Vollset, S. E., Ikuta, K. S., Swetschinski, L. R., Gray, A. P., Wool, E. E., Robles Aguilar, G., Mestrovic, T., Smith, G., Han, C., Hsu, R. L., Chalek, J., Araki, D. T., Chung, E., Raggi, C., Gershberg Hayoon, A., Davis Weaver, N., Lindstedt, P. A., Smith, A. E., … Murray, C. J. L. (2024). Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050. The Lancet, 404(10459), 1199–1226. https://doi.org/10.1016/S0140-6736(24)01867-1

Niranjan, M., Vaishnav, V., & Mankar, P. (2020). In-vitro analysis of antioxidant and antimicrobial properties of Garcinia mangostana L. (pericarp) and Clitoria ternatea (flower). The Pharma Innovation, 9(3), 468–472.

Park, S. Y., Lee, J. H., Ko, S. Y., Kim, N., Kim, S. Y., & Lee, J. C. (2023). Antimicrobial activity of α-mangostin against Staphylococcus species from companion animals in vitro and therapeutic potential of α-mangostin in skin diseases caused by S. pseudintermedius. Frontiers in Cellular and Infection Microbiology, 13. https://doi.org/10.3389/fcimb.2023.1203663

Permana, A., Mazlan, N., Yusuf, E., Anua, S. M., Thang, T. Y., & Baktir, A. (2023). Synergistic effect of commercial mangosteen extract (Garcinia mangostana L.) and amoxicillin against methicillin-resistant Staphylococcus aureus (MRSA). International Food Research Journal, 30(5), 1313–1319. https://doi.org/10.47836/ifrj.30.5.19

Phitaktim, S., Chomnawang, M., Sirichaiwetchakoon, K., Dunkhunthod, B., Hobbs, G., & Eumkeb, G. (2016). Synergism and the mechanism of action of the combination of α-mangostin isolated from Garcinia mangostana L. and oxacillin against an oxacillin-resistant Staphylococcus saprophyticus. BMC Microbiology, 16(1), 195. https://doi.org/10.1186/s12866-016-0814-4

Phumlek, K., Itharat, A., Pongcharoen, P., Chakkavittumrong, P., Lee, H.-Y., Moon, G.-S., Han, M.-H., Panthong, S., Ketjinda, W., & Davies, N. M. (2022). Garcinia mangostana hydrogel patch. Research in Pharmaceutical Sciences, 17(5), 457–467. https://doi.org/10.4103/1735-5362.355195

Pohan, D. J., & Rahmawati, F. (2022). The effect of mangosteen pericarp (Garcinia mangostana Linn) extract on inhibits the growth of bacteria Escherichia Coli ATCC 25922 and bacteria Staphylococcus Aureus ATCC 25923. International Journal of Research in Pharmacy and Pharmaceutical Sciences, 7(2), 29–38.

Praptiningsih, R. S., Pratiwi, R., & Nurafifah, T. Y. (2023). Alfa Mangostin Extract (Garcinia Mangostana L) Effectiveness on the Biofilm Thickness Growth of Streptococcus Sanguinis. Odonto : Dental Journal, 10, 7. https://doi.org/10.30659/odj.10.0.7-14

Rachmawati, W., Hasanah, A. N., Muttaqin, F. Z., & Muchtaridi, M. (2024). Design, synthesis, and characterization of molecularly imprinted solid phase extraction for alpha Mangostin analysis in blood sample. Polymers for Advanced Technologies, 35(2). https://doi.org/10.1002/pat.6316

Rajendran, T., Pandurangan, P., Varadharajan, R. K., Pannerselvam, A., & Gopakumaran, N. (2024). Garcinia mangostana A Comprehensive Overview of Ethnomedicine, Phytochemistry, Toxicological and in Silico Analysis. Biointerface Research in Applied Chemistry, 14(1), 7. https://doi.org/10.33263/BRIAC141.007

Sari, G. N. F., & Turahman, T. (2018). Aktivitas Antibakteri Ekstrak dan Fraksi Daun Manggis (Garcinia mangostana) terhadap Staphylococcus aureus dan Pseudomonas aeruginosa. Prosiding Seminar Nasional Unimus, 1, 767–771.

Sitti, R. H. S., Sugita, P., Ambarsari, L., & Rahayu, D. U. C. (2018). Antibacterial Mangosteen (Garcinia mangostana Linn.) peel extract encapsulated in Chitosan. Journal of Physics: Conference Series, 1116, 042037. https://doi.org/10.1088/1742-6596/1116/4/042037

Suhandi, C., Fadhilah, E., Silvia, N., Atusholihah, A., Prayoga, R. R., Megantara, S., & Muchtaridi, M. (2021). Molecular Docking Study of Mangosteen (Garcinia mangostana L.) Xanthone-Derived Isolates as Anti Androgen. Indonesian Journal of Cancer Chemoprevention, 12(1), 11. https://doi.org/10.14499/indonesianjcanchemoprev12iss1pp11-20

Sujono, S., & Nuryati, A. (2017). Uji Antibakteri Ekstrak Metanol Kulit Buah Manggis (garcinia mangostana l.) Terhadap Staphyllococcus aureus dan Escherechia coli. Jurnal Teknologi Laboratorium, 6(1), 25–30.

Tangsuksan, P., Srichana, T., Kettratad, M., & Nittayananta, W. (2022). Antimicrobial and Anti-inflammatory Effects of α-Mangostin Soluble Film. Journal of International Society of Preventive & Community Dentistry, 12(2), 189–198. https://doi.org/10.4103/jispcd.JISPCD_222_21

Thiankam, S., Thonghuatoei, W., Kantha, P., Yomla, R., & Kitikiew, S. (2024). Efficacy of mangosteen (Garcinia mangostana) peel hot water extract against Aeromonas hydrophila infection of seabass fingerling (Lates calcarifer). International Journal of Agricultural Technology, 20(1), 381–398.

Wathoni, N., Yuan Shan, C., Yi Shan, W., Rostinawati, T., Indradi, R. B., Pratiwi, R., & Muchtaridi, M. (2019). Characterization and antioxidant activity of pectin from Indonesian mangosteen (Garcinia mangostana L.) rind. Heliyon, 5(8), e02299. https://doi.org/10.1016/j.heliyon.2019.e02299

Widowati, W., Darsono, L., Suherman, J., Fauziah, N., Maesaroh, M., & Erawijantari, P. P. (2016). Anti-inflammatory Effect of Mangosteen ( Garcinia mangostana L.) Peel Extract and its Compounds in LPS-induced RAW264.7 Cells. Natural Product Sciences, 22(3), 147. https://doi.org/10.20307/nps.2016.22.3.147

Widyarman, A., Lay, S., Wendhita, I., Tjakra, E., Murdono, F., & Binartha, C. O. (2019). Indonesian mangosteen fruit (Garcinia mangostana L.) peel extract inhibits Streptococcus mutans and Porphyromonas gingivalis in Biofilms In vitro. Contemporary Clinical Dentistry, 10(1), 123. https://doi.org/10.4103/ccd.ccd_758_18

Yostawonkul, J., Kamble, M. T., Sakuna, K., Madyod, S., Sukkarun, P., Medhe, S. V., Rodkhum, C., Pirarat, N., & Sewaka, M. (2023). Effects of Mangosteen (Garcinia mangostana) Peel Extract Loaded in Nanoemulsion on Growth Performance, Immune Response, and Disease Resistance of Nile Tilapia (Oreochromis niloticus) against Aeromonas veronii Infection. Animals, 13(11), 1798. https://doi.org/10.3390/ani13111798

Yuvanatemiya, V., Srean, P., Klangbud, W. K., Venkatachalam, K., Wongsa, J., Parametthanuwat, T., & Charoenphun, N. (2022). A Review of the Influence of Various Extraction Techniques and the Biological Effects of the Xanthones from Mangosteen (Garcinia mangostana L.) Pericarps. Molecules, 27(24), 8775. https://doi.org/10.3390/molecules27248775

Zhang, H., Tan, Y., Zhao, L., Wang, L., Fu, N., Zheng, S., & Shen, X. (2020). Anticancer activity of dietary xanthone α-mangostin against hepatocellular carcinoma by inhibition of STAT3 signaling via stabilization of SHP1. Cell Death & Disease, 11(1), 63. https://doi.org/10.1038/s41419-020-2227-4




DOI: https://doi.org/10.31764/lf.v7i1.36090

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